The best time to take Malegra 200 mg is primarily determined by when you plan to have sexual activity rather than a fixed time of day. Malegra contains Sildenafil, which usually starts working 30–60 minutes after ingestion and can remain effective for 4–6 hours. Therefore, it should be taken approximately one hour before sexual activity for optimal results. It is important to consider food intake. Taking Malegra after a heavy or fatty meal may delay absorption and reduce its effectiveness. A light meal or fasting state is preferable.