The Saturn in the twelfth house is responsible for the depression onto the native. Apart from that, this placement of Saturn in the horoscope indicates loss of property, mental stress, and loss of family wealth. But, this position of Saturn gives positive responses too. When Saturn is positively influenced in the 12th house, then it represents permanent settlement on foreign land. Saturn is considered a Karmic planet, as it is responsible for a person's deeds. Saturn 12th house gives malefic results like depression, mental stress, property loss, and family wealth. The person also acquires many hidden enemies from their own family.