What is Fioricet? Fioricet is a pain relief medication to treat headaches due to muscle contraction and migraines. It is a prescription medication to treat headaches and migraines. Fioricet is an analgesic barbiturate combo, and it is safe for children under 12 years of age. Fioricet is a very unique and potent formulation that provides long-lasting relief and sustained relief from headaches. Now you can buy Fioricet online as it is also an effective treatment for migraines. Although it will not cure the symptoms, it will provide pain relief from the headache.