Malegra DXT Plus is a combination medication containing sildenafil citrate (100 mg) and duloxetine hydrochloride (60 mg), designed to treat both erectile dysfunction (ED) and premature ejaculation (PE). While effective, it carries several important drug interaction warnings and safety precautions. Malegra DXT Plus can cause dizziness or drowsiness. Do not drive or operate heavy machinery until you know how this medication affects you.